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Literature summary extracted from

  • Joshi, A.; Bondada, V.; Geddes, J.W.
    Mitochondrial micro-calpain is not involved in the processing of apoptosis-inducing factor (2009), Exp. Neurol., 218, 221-227.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.52 calpastatin
-
 Rattus norvegicus
3.4.22.52 MDL-28170 Cbz-Val-Phel-alanial Rattus norvegicus
3.4.22.52 PD150606
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.52 mitochondrion a pool of micro-calpain is localized to the mitochondrial intermembrane space Rattus norvegicus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.22.52 Ca2+ incubation with 5 mM Ca2+ results in the activation of micro-calpain Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.52 80000
-
 SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.52 apoptosis-inducing factor + H2O Rattus norvegicus mitochondrial micro-calpain is the protease responsible for processing apoptosis-inducing factor prior to its release truncated apoptosis-inducing factor + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.52 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.52 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.52 apoptosis-inducing factor + H2O mitochondrial micro-calpain is the protease responsible for processing apoptosis-inducing factor prior to its release Rattus norvegicus truncated apoptosis-inducing factor + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.52 calpain 1
-
 Rattus norvegicus
3.4.22.52 micro-calpain
-
 Rattus norvegicus